The Mama River+ Program aims to address high maternal and neonatal mortality rates by empowering community agents to act as first-level service providers for pregnant women, to ensure adherence to adequate maternal and newborn care. Starting in the Peruvian Amazon, the project expects to enroll 1,150 mother-infant pairs living in extremely impoverished and remote regions. Based on the results from the proof-of-concept study, the goal is to increase the number of women initiating antenatal care in the first trimester by more than 60%.